Tinnitus with a normal audiogram: Relation to noise exposure but no evidence for cochlear synaptopathy
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منابع مشابه
Tinnitus with a normal audiogram: Relation to noise exposure but no evidence for cochlear synaptopathy
In rodents, exposure to high-level noise can destroy synapses between inner hair cells and auditory nerve fibers, without causing hair cell loss or permanent threshold elevation. Such "cochlear synaptopathy" is associated with amplitude reductions in wave I of the auditory brainstem response (ABR) at moderate-to-high sound levels. Similar ABR results have been reported in humans with tinnitus a...
متن کاملImpaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure
In rodents, noise exposure can destroy synapses between inner hair cells and auditory 1 nerve fibers (“cochlear synaptopathy”) without causing hair cell loss. Noise-induced 2 cochlear synaptopathy usually leaves cochlear thresholds unaltered, but is associated 3 with long-term reductions in auditory brainstem response (ABR) amplitudes at medium-to4 high sound levels. This pathophysiology has be...
متن کاملWeak Middle-Ear-Muscle Reflex in Humans with Noise-Induced Tinnitus and Normal Hearing May Reflect Cochlear Synaptopathy
Chronic tinnitus is a prevalent hearing disorder, and yet no successful treatments or objective diagnostic tests are currently available. The aim of this study was to investigate the relationship between the presence of tinnitus and the strength of the middle-ear-muscle reflex (MEMR) in humans with normal and near-normal hearing. Clicks were used as test stimuli to obtain a wideband measure of ...
متن کاملProlonged Exposure of CBA/Ca Mice to Moderately Loud Noise Can Cause Cochlear Synaptopathy but Not Tinnitus or Hyperacusis as Assessed With the Acoustic Startle Reflex
Hearing loss changes the auditory brain, sometimes maladaptively. When deprived of cochlear input, central auditory neurons become more active spontaneously and begin to respond more strongly and synchronously to better preserved sound frequencies. This spontaneous and sound-evoked central hyperactivity has been postulated to trigger tinnitus and hyperacusis, respectively. Localized hyperactivi...
متن کاملTinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model.
Ever since Pliny the Elder coined the term tinnitus, the perception of sound in the absence of an external sound source has remained enigmatic. Traditional theories assume that tinnitus is triggered by cochlear damage, but many tinnitus patients present with a normal audiogram, i.e., with no direct signs of cochlear damage. Here, we report that in human subjects with tinnitus and a normal audio...
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ژورنال
عنوان ژورنال: Hearing Research
سال: 2017
ISSN: 0378-5955
DOI: 10.1016/j.heares.2016.12.002